PSMA Expression in Solid Tumors beyond the Prostate Gland: Ready for Theranostic Applications?

ABSTRACT: In the past decades, the expanding use of prostate-specific membrane antigen (PSMA) imaging for prostate cancer has led to the incidental detection of a lot of extra-prostatic malignancies showing an increased uptake of PSMA. Due to these incidental findings, the increasing amount of immunohistochemistry studies and the deeper knowledge of the mechanisms of expression of this antigen, it is now clear that "PSMA" is a misnomer, since it is not specific to the prostate gland. Nevertheless, this lack of specificity could represent an interesting opportunity to bring new insights on the biology of PSMA and its sites of expression to image and treat new conditions, particularly several cancers. In this review, we will describe the main extra-prostatic cancers that exhibit PSMA expression and th

SUBMITTER: Lauri C 

PROVIDER: S-EPMC9657217 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature