The Stress Response of the Holothurian Central Nervous System: A Transcriptomic Analysis.

ABSTRACT: Injury to the central nervous system (CNS) results in permanent damage and lack of function in most vertebrate animals, due to their limited regenerative capacities. In contrast, echinoderms can fully regenerate their radial nerve cord (RNC) following transection, with little to no scarring. Investigators have associated the regenerative capacity of some organisms to the stress response and inflammation produced by the injury. Here, we explore the gene activation profile of the stressed holothurian CNS. To do this, we performed RNA sequencing on isolated RNC explants submitted to the stress of transection and enzyme dissection and compared them with explants kept in culture for 3 days following dissection. We describe stress-associated genes, including members of heat-shock families, ubiqu

SUBMITTER: Cruz-Gonzalez S 

PROVIDER: S-EPMC9657328 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature