On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder.

ABSTRACT: The behavioral and neural dynamics of response inhibition deficits in alcohol use disorder (AUD) are still largely unclear, despite them possibly being key to the mechanistic understanding of the disorder. Our study investigated the effect of automatic vs. controlled processing during response inhibition in participants with mild-to-moderate AUD and matched healthy controls. For this, a Simon Nogo task was combined with EEG signal decomposition, multivariate pattern analysis (MVPA), and source localization methods. The final sample comprised n = 59 (32♂) AUD participants and n = 64 (28♂) control participants. Compared with the control group, AUD participants showed overall better response inhibition performance. Furthermore, the AUD group was less influenced by the modulatory effect of aut

SUBMITTER: Ghin F 

PROVIDER: S-EPMC9657501 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature