Molecular and Cellular Interactions in Pathogenesis of Sporadic Parkinson Disease.

ABSTRACT: An increasing number of the population all around the world suffer from age-associated neurodegenerative diseases including Parkinson's disease (PD). This disorder presents different signs of genetic, epigenetic and environmental origin, and molecular, cellular and intracellular dysfunction. At the molecular level, α-synuclein (αSyn) was identified as the principal molecule constituting the Lewy bodies (LB). The gut microbiota participates in the pathogenesis of PD and may contribute to the loss of dopaminergic neurons through mitochondrial dysfunction. The most important pathogenetic link is an imbalance of Ca²⁺ ions, which is associated with redox imbalance in the cells and increased generation of reactive oxygen species (ROS). In this review, genetic, epigenetic and environme

SUBMITTER: Dolgacheva LP 

PROVIDER: S-EPMC9657547 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature