The Association between Gut Microbiome and Pregnancy-Induced Hypertension: A Nested Case-Control Study.

ABSTRACT: (1) Background: Pregnancy-induced hypertension (PIH) is associated with obvious microbiota dysbiosis in the third trimester of pregnancy. However, the mechanisms behind these changes remain unknown. Therefore, this study aimed to explore the relationship between the gut microbiome in early pregnancy and PIH occurrence. (2) Methods: A nested case-control study design was used based on the follow-up cohort. Thirty-five PIH patients and thirty-five matched healthy pregnant women were selected as controls. The gut microbiome profiles were assessed in the first trimester using metagenomic sequencing. (3) Results: Diversity analyses showed that microbiota diversity was altered in early pregnancy. At the species level, eight bacterial species were enriched in healthy controls: Alistipes putred

SUBMITTER: Lin H 

PROVIDER: S-EPMC9657571 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature