Optimization of Transpedicular Electrode Insertion for Electroporation-Based Treatments of Vertebral Tumors.

ABSTRACT: Electroporation-based treatments such as electrochemotherapy and irreversible electroporation ablation have sparked interest with respect to their use in medicine. Treatment planning involves determining the best possible electrode positions and voltage amplitudes to ensure treatment of the entire clinical target volume (CTV). This process is mainly performed manually or with computationally intensive genetic algorithms. In this study, an algorithm was developed to optimize electrode positions for the electrochemotherapy of vertebral tumors without using computationally intensive methods. The algorithm considers the electric field distribution in the CTV, identifies undertreated areas, and uses this information to iteratively shift the electrodes from their initial positions to cover the e

SUBMITTER: Cindric H 

PROVIDER: S-EPMC9657605 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature