Roles of LonP1 in Oral-Maxillofacial Developmental Defects and Tumors: A Novel Insight.

ABSTRACT: Recent studies have indicated a central role for LonP1 in mitochondrial function. Its physiological functions include proteolysis, acting as a molecular chaperone, binding mitochondrial DNA, and being involved in cellular respiration, cellular metabolism, and oxidative stress. Given its vital role in energy metabolism, LonP1 has been suggested to be associated with multi-system neoplasms and developmental disorders. In this study, we investigated the roles, possible mechanisms of action, and therapeutic roles of LonP1 in oral and maxillofacial tumor development. LonP1 was highly expressed in oral-maxillofacial cancers and regulated their development through a sig-naling network. LonP1 may therefore be a promising anticancer therapy target. Mutations in LONP1 have been found to be in

SUBMITTER: Ma H 

PROVIDER: S-EPMC9657610 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature