Effects of Substance P and Neurokinin A on the Contractile Activity of Inflamed Porcine Uterus.

ABSTRACT: Disturbances in uterine contractile activity contribute to the development of inflammation, and recent evidence indicates that tachykinins, including substance P (SP) and neurokinin A (NKA), are involved in controlling uterine function. Here, we determined the effect of Escherichia coli (E. coli)-induced inflammation on expression of protein receptor subtypes for substance P (NK1R) and neurokinin A (NK2R) in the pig myometrium as well as their role in contractility of inflamed uterus. The severe acute endometritis developed in the E. coli group and the expression of NK1R and NK2R proteins increased in the myometrium. Compared to the pre-administration period, SP (10^-6 M) reduced the amplitude and frequency in the myometrium of the E. coli group and th

SUBMITTER: Brzozowska M 

PROVIDER: S-EPMC9657707 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature