Preparation and Characterization of an Anticancer Peptide from Oriental Tonic Food Enteromorpha prolifera.

ABSTRACT: Enteromorpha prolifera (E. prolifera), a tonic food in East Asian countries, is frequently studied for their pharmaceutical and healthcare applications. However, limited research has focused on antitumor peptides derived from this edible seaweed. In this study, we aimed to investigate the anticancer properties of peptides isolated from the hydrolysate of E. prolifera generated by a plethora of proteases including trypsin, papain, bromelain, and alkaline protease. The results showed that the hydrolysate produced by papain digestion exhibited remarkably stronger anticancer activity and was subjected to further purification by ultrafiltration and sequential chromatography. One heptapeptide, designated HTDT-6-2-3-2, showed significant antiproliferation activity towards sev

SUBMITTER: Lin X 

PROVIDER: S-EPMC9657784 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature