Protein Arginine Methyltransferases as Therapeutic Targets in Hematological Malignancies.

ABSTRACT: Arginine methylation is a common post-translational modification affecting protein activity and the transcription of target genes when methylation occurs on histone tails. There are nine protein arginine methyltransferases (PRMTs) in mammals, divided into subgroups depending on the methylation they form on a molecule of arginine. During the formation and maturation of the different types of blood cells, PRMTs play a central role by controlling cell differentiation at the transcriptional level. PRMT enzymatic activity is necessary for many cellular processes in hematological malignancies, such as the activation of cell cycle and proliferation, inhibition of apoptosis, DNA repair processes, RNA splicing, and transcription by methylating histone tails' arginine. Chemical tools have been devel

SUBMITTER: Sauter C 

PROVIDER: S-EPMC9657843 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature