Focus on the Dynamics of Neutrophil-to-Lymphocyte Ratio in Cancer Patients Treated with Immune Checkpoint Inhibitors: A Meta-Analysis and Systematic Review.

ABSTRACT:

Background

A number of studies have reported an association between the dynamics of neutrophil-to-lymphocyte ratio (NLR) and clinical efficacy in patients treated with immune checkpoint inhibitors (ICIs), but there is still a lack of a meta-analysis or systematic review.

Methods

PubMed, Embase, Web of Science, and the Cochrane Library were searched until September 2022 for studies reporting on the association between the change in NLR after ICI treatment and clinical outcomes. Outcome measures of interest included: change in NLR before and after treatment, overall survival (OS), progression-free survival (PFS), and objective response rate (ORR).

Results

A total of 4154 patients in 38 studies were included. The pooled percentage of patients with increased NLR was 49.7%

SUBMITTER: Guo Y 

PROVIDER: S-EPMC9658132 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature