The Synthesis, Fungicidal Activity, and in Silico Study of Alkoxy Analogues of Natural Precocenes I, II, and III.

ABSTRACT: This study aimed to synthesize, characterize, and explore the eco-friendly and antifungal potential of precocenes and their derivatives. The organic synthesis of the mono-O-alkyl-2,2-dimethyl 2H-1-chromene series, including the natural product precocene I, and the di-O-alkyl 2,2-dimethyl-2H-1-chromene series, including the natural 2H-1-chromenes precocenes II and III, was achieved. The synthetic compounds were subjected to spectroscopic analysis, ¹HNMR,¹³CNMR, and mass characterization. The antifungal activity of synthesized precocenes I, II, and III, as well as their synthetic intermediates, was evaluated by the poison food technique. Precocene II (EC₅₀ 106.8 µg × mL^-1 and 4.94 µg mL^-1), and its regioisomer

SUBMITTER: Ramadan KMA 

PROVIDER: S-EPMC9658145 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature