Hydrogen Sulfide Regulates SERCA2a Ubiquitylation via Muscle RING Finger-1 S-Sulfhydration to Affect Cardiac Contractility in db/db Mice.

ABSTRACT: Hydrogen sulfide (H₂S), as a gasotransmitter, is involved in various pathophysiological processes. Diabetic cardiomyopathy (DCM) is a major complication of diabetes mellitus (DM), which leads to structural and functional abnormalities of the myocardium and eventually causes heart failure (HF). Systolic and diastolic dysfunction are fundamental features of heart failure. SERCA2a, as a key enzyme for calcium transport in the endoplasmic reticulum (ER), affects the process of myocardial relaxation and contraction. H₂S can protect the cardiac function against diabetic hearts, however, its mechanisms are unclear. This study found that exogenous H₂S affects cellular calcium transport by regulating the H₂S/MuRF1/SERCA2a/cardiac contractile pathway. Our

SUBMITTER: Peng S 

PROVIDER: S-EPMC9658184 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature