Coenzyme Q10 and Melatonin for the Treatment of Male Infertility: A Narrative Review.

ABSTRACT:

Background

Lifestyle and environmental factors can negatively impact fertility by means of oxidative stress. In this context, antioxidant supplementation therapy has gained much interest in recent years, and different molecules, alone or in combination, have been studied.

Objective

The purpose of the present review is to investigate the evidence regarding the efficacy of coenzyme Q10 (CoQ10) and melatonin on male infertility.

Methods

A literature search using PUBMED database from 2000 to October 2022 was performed to explore the role of CoQ10 and melatonin on male reproductive function.

Conclusions

The analysis involved a narrative synthesis. CoQ10, alone or in combination, appears to reduce testicular oxidative stress and sperm DNA fragmentation and to improve

SUBMITTER: Lucignani G 

PROVIDER: S-EPMC9658523 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature