Phytochemical Variability, In Vitro and In Vivo Biological Investigations, and In Silico Antibacterial Mechanisms of Mentha piperita Essential Oils Collected from Two Different Regions in Morocco.

ABSTRACT: The objective of this work is to explore the phytochemical profile of Mentha piperita essential oils (MPEO) collected from two different Moroccan regions using gas chromatography-mass spectrophotometer (GC-MS) and to investigate their antioxidant, anti-inflammatory, antidiabetic and, antimicrobial effects using in vivo and in vitro assays. The chemical constituent of MPEO from the Azrou zone is dominated by carvone (70.25%), while MPEO from the Ouazzane zone is rich in Menthol (43.32%) and Menthone (29.4%). MPEO from Ouezzane showed higher antioxidant activity than EO from Azrou. Nevertheless, EO from Ouezzane considerably inhibited 5-Lipoxygenase (IC₅₀ = 11.64 ± 0.02 µg/mL) compared to EO from Azro (IC₅₀ = 23.84 ± 0.03 µg/mL). Both EOs from Azrou and Ouazzane

SUBMITTER: Al-Mijalli SH 

PROVIDER: S-EPMC9658668 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature