The Roles of <i>MTRR</i> and <i>MTHFR</i> Gene Polymorphisms in Colorectal Cancer Survival.

ABSTRACT:

Background

Paradoxically epidemiological data illustrate a negative relationship between dietary folate intake and colorectal cancer (CRC) risk. The occurrence and progression of CRC may be influenced by variants in some key enzyme coding genes in the folate metabolic pathway. We investigated the correlation between genetic variants in methionine synthase reductase (MTRR) and methylenetetrahydrofolate reductase (MTHFR) and CRC survival.

Methods

This study used data collected from the Newfoundland Familial Colorectal Cancer Study. A total of 532 patients diagnosed with CRC for the first time from 1999 to 2003 were enrolled, and their mortality were tracked until April 2010. DNA samples were genotyped by Illumina's integrated quantum 1 million chip. Cox models we

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9658674 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature