Synthesis and Evaluation of 11-Butyl Matrine Derivatives as Potential Anti-Virus Agents.

ABSTRACT: Matrine derivatives were reported to have various biological activities, especially the ester, amide or sulfonamide derivatives of matrine deriving from the hydroxyl or carboxyl group at the end of the branch chain after the D ring of matrine is opened. In this work, to investigate whether moving away all functional groups from the C-11 branch chain could have an impact on the bioactivities, such as anti-tobacco mosaic virus (TMV), insecticidal and fungicidal activities, a variety of N-substituted-11-butyl matrine derivatives were synthesized. The obtained bioassay result showed that most N-substituted-11-butyl matrine derivatives had obviously enhanced anti-TMV activity compared with matrine, especially many compounds had good inhibitory activity close to that of commerciali

SUBMITTER: Ni W 

PROVIDER: S-EPMC9658933 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature