Integrating Genomic Information with Tumor-Immune Microenvironment in Triple-Negative Breast Cancer.

ABSTRACT:

Background

the development and progression of triple-negative breast cancer (TNBC) is driven by somatic driver mutations and the tumor-immune microenvironment. To date, data on somatic mutations has not been leveraged and integrated with information on the immune microenvironment to elucidate the possible oncogenic interactions and their potential effects on clinical outcomes. Here, we investigated possible oncogenic interactions between somatic mutations and the tumor-immune microenvironment, and their correlation with patient survival in TNBC.

Methods

We performed analysis combining data on 7,875 somatic mutated genes with information on 1,751 immune-modulated genes, using gene-expression data as the intermediate phenotype, and correlated the resulting information with sur

SUBMITTER: Otohinoyi D 

PROVIDER: S-EPMC9659069 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature