Spatial Memory Training Counteracts Hippocampal GIRK Channel Decrease in the Transgenic APP_Sw,Ind J9 Alzheimer's Disease Mouse Model.

ABSTRACT: G-protein-gated inwardly rectifying potassium (GIRK) channels are critical determinants of neuronal excitability. They have been proposed as potential targets to restore excitatory/inhibitory balance in acute amyloidosis models, where hyperexcitability is a hallmark. However, the role of GIRK signaling in transgenic mice models of Alzheimer's disease (AD) is largely unknown. Here, we study whether progressive amyloid-β (Aβ) accumulation in the hippocampus during aging alters GIRK channel expression in mutant β-amyloid precursor protein (APP_Sw,Ind J9) transgenic AD mice. Additionally, we examine the impact of spatial memory training in a hippocampal-dependent task, on protein expression of GIRK subunits and Regulator of G-protein signaling 7 (RGS7) in the hippocampus of APP_S

SUBMITTER: Temprano-Carazo S 

PROVIDER: S-EPMC9659077 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature