The Role of MicroRNAs in Dilated Cardiomyopathy: New Insights for an Old Entity.

ABSTRACT: Dilated cardiomyopathy (DCM) is a clinical diagnosis characterized by left ventricular or biventricular dilation and systolic dysfunction. In most cases, DCM is progressive, leading to heart failure (HF) and death. This cardiomyopathy has been considered a common and final phenotype of several entities. DCM occurs when cellular pathways fail to maintain the pumping function. The etiology of this disease encompasses several factors, such as ischemia, infection, autoimmunity, drugs or genetic susceptibility. Although the prognosis has improved in the last few years due to red flag clinical follow-up, early familial diagnosis and ongoing optimization of treatment, due to its heterogeneity, there are no targeted therapies available for DCM based on each etiology. Therefore, a better understand

SUBMITTER: Alonso-Villa E 

PROVIDER: S-EPMC9659086 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature