Social Hierarchy Dictates Intestinal Radiation Injury in a Gut Microbiota-Dependent Manner.

ABSTRACT: Social hierarchy governs the physiological and biochemical behaviors of animals. Intestinal radiation injuries are common complications connected with radiotherapy. However, it remains unclear whether social hierarchy impacts the development of radiation-induced intestinal toxicity. Dominant mice exhibited more serious intestinal toxicity following total abdominal irradiation compared with their subordinate counterparts, as judged by higher inflammatory status and lower epithelial integrity. Radiation-elicited changes in gut microbiota varied between dominant and subordinate mice, being more overt in mice of higher status. Deletion of gut microbes by using an antibiotic cocktail or restructuring of the gut microecology of dominant mice by using fecal microbiome from their subordinate compa

SUBMITTER: Zeng X 

PROVIDER: S-EPMC9659279 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature