Docosahexaenoic Acid Counteracts the Hypoxic-Induced Inflammatory and Metabolic Alterations in 3T3-L1 Adipocytes.

ABSTRACT:

Background

Hypoxia is caused by the excessive expansion of the white adipose tissue (AT) and is associated with obesity-related conditions such as insulin resistance, inflammation, and oxidative stress. Docosahexaenoic acid (DHA) is an omega-3 fatty acid reported to have beneficial health effects. However, the effects of DHA in AT against hypoxia-induced immune-metabolic perturbations in adipocytes exposed to low O₂ tension are not well known. Consequently, this study aimed to evaluate the impact of DHA on markers of inflammation, metabolism, apoptosis, and oxidative stress in 3T3-L1 cell adipocytes exposed to low O₂ tension (1% O₂) induced hypoxia.

Methods

The apoptosis and reactive oxygen species (ROS) rates were evaluated. Metabolic parame

SUBMITTER: Younes NB 

PROVIDER: S-EPMC9659308 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature