Two intrinsic timing mechanisms set start and end times for dendritic arborization of a nociceptive neuron.

ABSTRACT: Choreographic dendritic arborization takes place within a defined time frame, but the timing mechanism is currently not known. Here, we report that the precisely timed lin-4-lin-14 regulatory circuit triggers an initial dendritic growth activity, whereas the precisely timed lin-28-let-7-lin-41 regulatory circuit signals a subsequent developmental decline in dendritic growth ability, hence restricting dendritic arborization within a set time frame. Loss-of-function mutations in the lin-4 microRNA gene cause limited dendritic outgrowth, whereas loss-of-function mutations in its direct target, the lin-14 transcription factor gene, cause precocious and excessive outgrowth. In contrast, loss-of-function mutations in the let-7 microRNA gene prevent a developmen

SUBMITTER: Suzuki N 

PROVIDER: S-EPMC9659368 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature