Control of resistance against bacteriophage killing by a metabolic regulator in meningitis-associated Escherichia coli.

ABSTRACT: Ecologically beneficial traits in bacteria are encoded by intrinsic and horizontally acquired genes. However, such traits are not universal, and the highly mosaic nature of bacterial genomes requires control at the transcriptional level to drive these processes. It has emerged that regulatory flexibility is widespread in the Escherichia coli species, whereby preexisting transcription factors can acquire new and unrelated roles in regulating beneficial traits. DsdC is the regulator of D-serine tolerance in E. coli, is essential for D-serine catabolism, and is often encoded by two copies in neonatal meningitis-associated E. coli (NMEC). Here, we reveal that DsdC is a global regulator of transcription in NMEC and does not require D-serine for the control of

SUBMITTER: Connolly JPR 

PROVIDER: S-EPMC9659370 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature