Phylodynamic signatures in the emergence of community-associated MRSA.

ABSTRACT: Community-associated, methicillin-resistant Staphylococcus aureus (MRSA) lineages have emerged in many geographically distinct regions around the world during the past 30 y. Here, we apply consistent phylodynamic methods across multiple community-associated MRSA lineages to describe and contrast their patterns of emergence and dissemination. We generated whole-genome sequencing data for the Australian sequence type (ST) ST93-MRSA-IV from remote communities in Far North Queensland and Papua New Guinea, and the Bengal Bay ST772-MRSA-V clone from metropolitan communities in Pakistan. Increases in the effective reproduction number (R_e) and sustained transmission (R_e > 1) coincided with spread of progenitor methicillin-susceptible S. aureus (MSSA) in remote n

SUBMITTER: Steinig E 

PROVIDER: S-EPMC9659408 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature