Tmem45b is essential for inflammation- and tissue injury-induced mechanical pain hypersensitivity.

ABSTRACT: Persistent mechanical pain hypersensitivity associated with peripheral inflammation, surgery, trauma, and nerve injury impairs patients' quality of life and daily activity. However, the molecular mechanism and treatment are not yet fully understood. Herein, we show that chemical ablation of isolectin B4-binding (IB4⁺) afferents by IB4-saporin injection into sciatic nerves completely and selectively inhibited inflammation- and tissue injury-induced mechanical pain hypersensitivity while thermal and mechanical pain hypersensitivities were normal following nerve injury. To determine the molecular mechanism involving the specific types of mechanical pain hypersensitivity, we compared gene expression profiles between IB4⁺ neuron-ablated and control dorsal root ganglion (DR

SUBMITTER: Tanioku T 

PROVIDER: S-EPMC9659417 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature