Adverse events, side effects and complications in mesenchymal stromal cell-based therapies.

ABSTRACT: Numerous clinical studies have shown a wide clinical potential of mesenchymal stromal cells (MSCs) application. However, recent experience has accumulated numerous reports of adverse events and side effects associated with MSCs therapy. Furthermore, the strategies and methods of MSCs therapy did not change significantly in recent decades despite the clinical impact and awareness of potential complications. An extended understanding of limitations could lead to a wider clinical implementation of safe cell therapies and avoid harmful approaches. Therefore, our objective was to summarize the possible negative effects observed during MSCs-based therapies. We were also aimed to discuss the risks caused by weaknesses in cell processing, including isolation, culturing, and storage. Cell processin

SUBMITTER: Baranovskii DS 

PROVIDER: S-EPMC9659480 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature