Impact of antibiotics on off-target infant gut microbiota and resistance genes in cohort studies.

ABSTRACT:

Background

Young children are frequently exposed to antibiotics, with the potential for collateral consequences to the gut microbiome. The impact of antibiotic exposures to off-target microbes (i.e., bacteria not targeted by treatment) and antibiotic resistance genes (ARGs) is poorly understood.

Methods

We used metagenomic sequencing data from paired stool samples collected prior to antibiotic exposure and at 1 year from over 200 infants and a difference-in-differences approach to assess the relationship between subsequent exposures and the abundance or compositional diversity of microbes and ARGs while adjusting for covariates.

Results

By 1 year, the abundance of multiple species and ARGs differed by antibiotic exposure. Compared to infants never exposed to antibioti

SUBMITTER: Lebeaux RM 

PROVIDER: S-EPMC9659678 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature