The SON₂A₂ score: A novel grading scale for predicting hemorrhage and outcomes after thrombolysis.

ABSTRACT:

Objectives

This study aimed to develop a score including novel putative predictors for predicting the risk of sICH and outcomes after thrombolytic therapy with intravenous (IV) recombinant tissue-type plasminogen activator (r-tPA) in acute ischemic stroke patients.

Methods

All patients with acute ischemic stroke treated with IV r-tPA at three university-based hospitals in Chongqing, China, from 2014 to 2019 were retrospectively studied. Potential risk factors associated with sICH (NINDS criteria) were determined with multivariate logistic regression, and we developed our score according to the magnitude of logistic regression coefficients. The score was validated in another independent cohort. Area under the receiver operating characteristic curve (AUC-ROC) was used to asses

SUBMITTER: Ren Y 

PROVIDER: S-EPMC9659729 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature