Polygenic hazard score modified the relationship between hippocampal subfield atrophy and episodic memory in older adults.

ABSTRACT:

Background

Understanding genetic influences on Alzheimer's disease (AD) may improve early identification. Polygenic hazard score (PHS) is associated with the age of AD onset and cognitive decline. It interacts with other risk factors, but the nature of such combined effects remains poorly understood.

Materials and methods

We examined the effect of genetic risk and hippocampal atrophy pattern on episodic memory in a sample of older adults ranging from cognitively normal to those diagnosed with AD using structural MRI. Participants included 51 memory unimpaired normal control (NC), 69 mild cognitive impairment (MCI), and 43 AD adults enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Hierarchical linear regression analyses examined the main and interaction eff

SUBMITTER: Xu J 

PROVIDER: S-EPMC9659745 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature