Differences of macrophages in the tumor microenvironment as an underlying key factor in glioma patients.

ABSTRACT:

Background

Macrophages, the major immune cells in glioma microenvironment, are closely related to tumor prognosis. Further studies are needed to investigate macrophages, which will be helpful to fully understand the role of it and early achieve clinical translation.

Methods

A total of 1334 glioma cases were enrolled in this study from 3 databases. In our works, the single cell cohorts from GSE89567, GSE84465, and the Chinese Glioma Genome Atlas (CGGA) datasets were used to analyze the key genes of macrophage. The bulk sequencing data from the Cancer Genome Atlas (TCGA) and CGGA datasets were respectively divided into the training set and validation set to test prognostic value of the key genes from single cell analysis.

Results

Quantitative and functional differences

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9659848 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature