Role of local therapy in the management of patients with metastatic anal squamous cell carcinoma: a National Cancer Database study.

ABSTRACT:

Background

About 10-20% of patients with anal squamous cell carcinoma (SCCa) present with metastatic disease and are usually treated with systemic chemotherapy. However, primary tumor control is crucial as local failure is associated with significant morbidity. Using the largest cohort to date, we report the impact of local therapy on survival among patients with metastatic anal SCCa.

Methods

Data were collected from US hospitals that contributed to the National Cancer Database (NCDB) between 2004 and 2015. Patients who did not receive palliative systemic chemotherapy were excluded from analysis. Univariate (UVA) and multivariable analyses (MVA) were performed to identify factors associated with patient outcome. Kaplan-Meier analysis and Cox proportional hazards models were

SUBMITTER: Atallah RP 

PROVIDER: S-EPMC9660037 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature