TRPV3 inhibits colorectal cancer cell proliferation and migration by regulating the MAPK signaling pathway.

ABSTRACT:

Background

The aim of this study was to investigate the inhibiting effect of transient receptor potential vanilloid 3 (TRPV3) on the proliferation and migration of colorectal cancer (CRC) cells and to explore the underlying mechanism.

Methods

A microarray dataset from the publicly available Gene Expression Omnibus (GEO) database was used to investigate the prognostic value of TRPV3 in CRC. In addition, 100 CRC tissue samples were collected at our center to further validate its prognostic value at the protein level. Cell proliferation ability was detected by Cell Counting Kit-8 (CCK-8) assay, and cell migration ability was detected by transwell assay. Gene set variation analysis (GSVA) was performed to identify the potential pathways regulated by TRPV3.

Results

Based o

SUBMITTER: Yu W 

PROVIDER: S-EPMC9660048 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature