The clinical effect of conversion surgery for advanced gastric cancer patients with peritoneal metastasis.

ABSTRACT:

Background

The prognosis of gastric cancer (GC) patients with peritoneal metastasis (PM) is extremely poor. We developed a new promising regimen combining intraperitoneal (i.p.) paclitaxel (PTX) with systemic PTX and S-1 chemotherapy for GC patients with PM. However, the value of conversion surgery (CS) for GC patients with PM remains unclear. This study aimed to clarify the clinical effect of CS from our updated previous report.

Methods

We retrospectively analyzed 50 GC patients, divided into chemotherapy alone (CTx; n=15) and conversion surgery intervention (CSI; n=35) groups. In the CTx group, chemotherapy was continued in responders, while in the CSI group, surgery was performed in chemotherapy-responders. The primary endpoint was overall survival (OS) of the two

SUBMITTER: Shinkai M 

PROVIDER: S-EPMC9660049 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature