STING promotes proliferation and induces drug resistance in colorectal cancer by regulating the AMPK-mTOR pathway.

ABSTRACT:

Background

In recent years, reports regarding stimulator of interferon genes (STING) and the progression of colorectal cancer (CRC) have emerged rapidly, yet their association remains controversial. This research was aimed to provide an insight into the prognostic biomarker and therapeutic target significance of STING in CRC.

Methods

CRC Cell lines of HCT116 and SW480, as well as 32 paired CRC specimens were chosen for this study. STING expressions were examined by immunohistochemistry to evaluate the correlation with clinicopathological factors. Data analysis of STING expressions in colon cancer and rectal cancer were performed using The Cancer Genome Atlas (TCGA) database. siRNA was transfected into cell lines for knocking down the expression of STING. Transwell assay was

SUBMITTER: Yao H 

PROVIDER: S-EPMC9660059 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature