Collagen XV mediated the epithelial-mesenchymal transition to inhibit hepatocellular carcinoma metastasis.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a malignant cancer with rapid progression, vascular invasion, a high recurrence rate and poor prognosis, so it is necessary to take early measures to halt this process. Accumulating evidence indicates that collagen XV (translated by Col15a1) is a basement membrane molecule related to tumour metastasis in several organs. However, the potential function of collagen XV in the liver associated with HCC remains to be further elucidated.

Methods

Col15a1 was overexpressed in HepG2 and HCCLM3 cells. CCK8 and colony formation assays were used to assess the capacity of cell proliferation, and Transwell and wound healing assays were utilized to measure cell migration. Western blotting and real-time quantitative reverse transcription polymera

SUBMITTER: Yao T 

PROVIDER: S-EPMC9660072 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature