A randomized controlled trial of positive end-expiratory pressure on pulmonary oxygenation and biventricular function in esophageal cancer patients receiving one-lung ventilation under a lower FiO₂.

ABSTRACT:

Background

Arterial oxygenation is often impaired during one-lung ventilation (OLV), due to both pulmonary shunt and atelectasis. Lower fraction of inspiration O₂ (FiO₂) may reduce inflammation and complications, but may increase the risk of hypoxemia. The aim of this randomized controlled parallel trial was to analyze whether higher positive end-expiratory pressure (PEEP) could improve oxygenation and maintain lower levels of inflammation during OLV under a lower FiO₂.

Methods

One hundred and twenty patients with selective thoracotomy for esophageal cancer (EC) were classified randomly into four groups on a ratio of 1:1:1:1 using a computer-generated list, including Group A (FiO₂ =0.6, PEEP =0), Group B (FiO₂ =0.6, PEEP

SUBMITTER: Li P 

PROVIDER: S-EPMC9660073 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature