SGLT-2 as a potential target in pancreatic cancer: the preliminary clue from The Cancer Genome Atlas data.

ABSTRACT:

Background

Sodium-glucose co-transporters-2 (SGLT-2) has been reported as overexpressed in tumors including pancreatic cancer (PC). The aim of this study was to investigate the clinicopathological and prognostic significance, as well as the potential role of SGLT-2 in PC development and progression.

Methods

The expression of SGLT-2 was assessed using The Cancer Genome Atlas (TCGA) PC dataset (179 cases). The overall survival (OS) and disease-free survival (DFS) of PC patients with high and low SLC5A2 expression were compared using the online database Gene Expression Profiling Interactive Analysis (GEPIA). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using The Database for Annotation Visualizati

SUBMITTER: Qiang W 

PROVIDER: S-EPMC9660074 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature