Cost-effectiveness of screening with polymerase chain reaction for Helicobacter pylori to prevent gastric cancer and peptic ulcers.

ABSTRACT:

Background

Helicobacter pylori (H. pylori) is a major risk factor for gastric cancer. Screening and treatment of H. pylori may reduce the risk of gastric cancer and peptic ulcer disease (PUD). Polymerase chain reaction (PCR) of gastric biopsies provides superior sensitivity and specificity for the detection of H. pylori. This study explores whether population-based H. pylori screening with PCR is cost-effective in the US.

Methods

A Markov cohort state-transition model was developed to compare three strategies: no screening with opportunistic eradication, ¹³C-UBT population screening and treating of H. pylori, and PCR population screening and treating of H. pylori. Estimates of risks and costs were obtained from publ

SUBMITTER: Oh A 

PROVIDER: S-EPMC9660075 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature