Construction of a co-expression network and prediction of metastasis markers in colorectal cancer patients with liver metastasis.

ABSTRACT:

Background

Colorectal cancer (CRC) is a common global malignancy associated with high invasiveness, high metastasis, and poor prognosis. CRC commonly metastasizes to the liver, where the treatment of metastasis is both difficult and an important topic in current CRC management.

Methods

Microarrays data of human CRC with liver metastasis (CRCLM) were downloaded from the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database to identify potential key genes. Differentially expressed (DE) genes (DEGs) and DEmiRNAs of primary CRC tumor tissues and metastatic liver tissues were identified. Microenvironment Cell Populations (MCP)-counter was used to estimate the abundance of immune cells in the tumor micro-environment (TME), and weighted gene co

SUBMITTER: Lin L 

PROVIDER: S-EPMC9660078 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature