Regulatory T cell therapy suppresses inflammation of oral mucosa.

ABSTRACT: Oral inflammatory diseases, including oral lichen planus (OLP) and recurrent aphthous ulcer (RAU), seriously affect the patient's quality of life. Due to the lack of ideal disease models, it is difficult to determine whether novel immunotherapy strategies are effective in treating oral inflammatory diseases. Here, we show that the deficiency of Foxp3 or IL-2 caused oral mucosa inflammation in mice, proving that Treg cells are important in maintaining the immune homeostasis in the oral mucosa. Then we determined that adoptive transfer of CD4⁺CD25^-CD45Rb^high T cells could induce oral inflammation in Rag1 ^-/- mice, and co-transfer of Treg cells together with CD4⁺CD25^-CD45Rb^high T cells could suppress the devel

SUBMITTER: Xue N 

PROVIDER: S-EPMC9660253 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature