Exploring the association of interleukin polymorphisms with aggression and internalizing behaviors in children and adolescents.

ABSTRACT:

Background

There is growing evidence that inflammation influences mental health. Blood interleukin levels, which regulate inflammation, have been linked to aggression and internalizing behaviors. We performed a hypothesis-driven genetic study to (1) evaluate the association of IL1B, IL2, and IL6 gene variants with aggression and internalizing behaviors and (2) explore gene-environment interactions with childhood adversity in a deeply phenotyped childhood-onset aggression sample including 255 cases and 226 controls of European ancestry.

Methods

We evaluated the association of putative functional and tag SNPs within IL1B, IL2, and IL6 with aggression case status, parent-reported internalizing problems, self-reported anxiety symptoms, and self-reported depressive symptoms in ou

SUBMITTER: Pouget JG 

PROVIDER: S-EPMC9660418 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature