Structural brain abnormalities in endothelial nitric oxide synthase-deficient mice revealed by high-resolution magnetic resonance imaging.

ABSTRACT:

Introduction

Endothelial nitric oxide synthase (eNOS) produces nitric oxide, which is essential for a variety of physiological functions in the brain. Previous work has demonstrated the detrimental effects of eNOS deficiency on brain function in male eNOS knockout (eNOS KO) mice. However, the effect of eNOS deficiency on brain structure and any association between these effects and sex is unknown.

Methods

This study used three-dimensional high-resolution ex vivo magnetic resonance imaging and behavioral tests of anxiety and cognitive performance to investigate structure-function relationships in the brain of female and male eNOS KO mice in young adulthood.

Results

While there were no differences in anxiety-like behavior or locomotion, there was a sex-specific deficit

SUBMITTER: George H 

PROVIDER: S-EPMC9660425 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature