Transcriptome alterations in chicken HD11 cells with steady knockdown and overexpression of RIPK2 gene.

ABSTRACT: Receptor interacting protein kinase 2 (RIPK2) is involved in a variety of signaling pathway to produce a series of inflammatory cytokines in response to a diverse of bacterial, viral and protozoal pathogens. However, the underlying regulating of RIPK2 remain unknown. Transcriptome alterations in chicken HD11 cells following RIPK2 overexpression or silencing by shRNA were analyzed by next-generation sequencing. Both overexpression and knockdown of the RIPK2 gene caused wide-spread changes in gene expression in chicken HD11 cells. Differentially expressed genes (DEGs) caused by altered RIPK2 gene expression were associated with multiple biological processes linked with biological regulation, response to stimulus, cell communication, and signal transduction etc. KEGG analysis revealed that ma

SUBMITTER: Hong-Yan S 

PROVIDER: S-EPMC9660593 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature