Structure-function subsystem model and computational lesions of the central nervous system's rostral sector (forebrain and midbrain).

ABSTRACT: The craniote central nervous system has been divided into rostral, intermediate, and caudal sectors, with the rostral sector containing the vertebrate forebrain and midbrain. Here, network science tools were used to create and analyze a rat hierarchical structure-function subsystem model of intrarostral sector neural connectivity between gray matter regions. The hierarchy has 109 bottom-level subsystems and three upper-level subsystems corresponding to voluntary behavior control, cognition, and affect; instinctive survival behaviors and homeostasis; and oculomotor control. As in previous work, subsystems identified based on their coclassification as network communities are revealed as functionally related. We carried out focal perturbations of neural structural connectivity comprehensively

SUBMITTER: Swanson LW 

PROVIDER: S-EPMC9661186 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature