AhRR methylation contributes to disease progression in urothelial bladder cancer.

ABSTRACT:

Background

Bladder Cancer (BCa) is the tenth most incident malignancy worldwide. BCa is mostly attributed to environmental exposure and lifestyle, particularly tobacco smoking. The Aryl Hydrocarbon Receptor Repressor (AhRR) participates in the induction of many enzymes involved in metabolizing carcinogens, including tobacco smoke components. Additionally, studies have shown that smoking demethylates the (AhRR) gene in blood, suggesting AhRR demethylation as a specific serum smoking biomarker.

Objective

This study aimed to validate AhRR demethylation as a smoking biomarker in the target tissue and investigate its contribution to bladder carcinogenesis.

Methods

AhRR percent methylation was tested for its association with patient smoking status and oncogenic outcome indi

SUBMITTER: El-Haddad NW 

PROVIDER: S-EPMC9661316 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature