Cancer and Vascular Comorbidity Effects on Dementia Risk and Neuropathology in the Oldest-Old.

ABSTRACT:

Background

Dementia, vascular disease, and cancer increase with age, enabling complex comorbid interactions. Understanding vascular and cancer contributions to dementia risk and neuropathology in oldest-old may improve risk modification and outcomes.

Objective

Investigate the contributions of vascular factors and cancer to dementia and neuropathology.

Methods

Longitudinal clinicopathologic study of prospectively followed Mayo Clinic participants dying≥95 years-old who underwent autopsy. Participants were stratified by dementia status and compared according to demographics, vascular risk factors, cancer, and neuropathology.

Results

Participants (n = 161; 83% female; 99% non-Hispanic whites)≥95 years (95-106 years-old) with/without dementia did not differ based o

SUBMITTER: Lachner C 

PROVIDER: S-EPMC9661335 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature