Exploring Network Properties Across Preclinical Stages of Alzheimer's Disease Using a Visual Short-Term Memory and Attention Task with High-Density Electroencephalography: A Brain-Connectome Neurophysiological Study.

ABSTRACT:

Background

Visual short-term memory (VSTMT) and visual attention (VAT) exhibit decline in the Alzheimer's disease (AD) continuum; however, network disruption in preclinical stages is scarcely explored.

Objective

To advance our knowledge about brain networks in AD and discover connectivity alterations during VSTMT and VAT.

Methods

Twelve participants with AD, 23 with mild cognitive impairment (MCI), 17 with subjective cognitive decline (SCD), and 21 healthy controls (HC) were examined using a neuropsychological battery at baseline and follow-up (three years). At baseline, the subjects were examined using high density electroencephalography while performing a VSTMT and VAT. For exploring network organization, we constructed weighted undirected networks and examined clus

SUBMITTER: Lazarou I 

PROVIDER: S-EPMC9661343 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature