Clinical Progression of Baseline Risk States for Mild Cognitive Impairment.

ABSTRACT:

Background

This memory-clinic study joins efforts to study earliest clinical signs and symptoms of Alzheimer's disease and related dementias: subjective reports and objective neuropsychological test performance.

Objective

The memory-clinic denoted two clinical "grey zones": 1) subjective cognitive decline (SCD; n = 107) with normal objective test scores, and 2) isolated low test scores (ILTS; n = 74) without subjective complaints to observe risk for future decline.

Methods

Initial and annual follow-up clinical research evaluations and consensus diagnosis were used to evaluate baseline characteristics and clinical progression over 2.7 years, compared to normal controls (NC; n = 117).

Results

The ILTS group was on average older than the NC and SCD groups. They ha

SUBMITTER: Goldberg SM 

PROVIDER: S-EPMC9661415 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature