The ventilatory response to hypoxia is blunted in some preterm infants during the second year of life.

ABSTRACT:

Background

Preterm birth and subsequent neonatal ventilatory treatment disrupts development of the hypoxic ventilatory response (HVR). An attenuated HVR has been identified in preterm neonates, however it is unknown whether the attenuation persists into the second year of life. We investigated the HVR at 12-15 months corrected postnatal age and assessed predictors of a blunted HVR in those born very preterm (<32 weeks gestation).

Methods

HVR was measured in infants born very preterm. Hypoxia was induced with a three-step reduction in their fraction of inspired oxygen (F_IO₂) from 0.21 to 0.14. Respiratory frequency (f), tidal volume (V _T), minute ventilation (V _E), inspiratory time (t _I), expir

SUBMITTER: Freislich Z 

PROVIDER: S-EPMC9661422 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature